Introduction: The present study was conducted to verify a promising experimental setup which demonstrated an inversed Stroop-effect following a mismatching tone. In the matching condition, which was an almost exact replication of the original study, participants were required to indicate whether word color and word meaning were matching, whereas in the response conflict condition, instruction was the same as in a classical Stroop task and required the participants to respond to the word color. As in the original study, each trial (...) was preceded by a sine tone which was deviant in pitch in 20% of the trials.Results: The main result was that the Stroop effect was not inversed after deviant tones, neither under the matching task instruction nor under the response conflict task instruction. The Stroop effect was unaffected by the previous “conceptual mismatch.”Conclusion: The current study failed to replicate the astonishing concept of “conflict priming” reported in previous work and does not open the doors for a new window on sequences of conflicts. Nevertheless, the failed replication is valuable for future research, since it demonstrated that “Conflict Priming” as a facilitation of processing of conflict trials following deviant tones, is not an confirmed finding. (shrink)

Changing faces of war and war-like situations have led in recent years to new forms of military deployment. They range from the so called "war on terrorism" with e.g Operation Enduring Freedom or humanitarian interventions (e.g. Kosovo 1999) to deployments within disaster relief missions as lately in Haiti. These pose not only moral, legal, and organizational challenges to states and the international community but also put individual soldiers and military (medical) personnel in situations that their classical formation does not prepare (...) them for. For they face (i) situations not sufficiently covered/ regulated by international humanitarian (IHL) law and/or (ii) tasks that are not within the range of the "classical soldier". These changing needs require new forms of education in the military and highlight the role of ethical education as many of the dilemmas cannot be resolved by sole reference to the IHL. In addition to a solid knowledge of the law of armed conflict (LOAC), military personnel should therefore acquire fundamental skills of ethical reasoning in dilemma situations. Our article aims at (i) outlining the goals of a military medical ethics education that responds to these needs and the practical challenges of present-day military deployment and (ii) present how the ICMM tries to integrate these goals in its educational program. (shrink)

The concepts of regulation and homeostasis are of frequent use but lack a single universally accepted definition. Here we propose a definition of theregulatory strength andhomeostatic strength, which allow to assess the importance of a regulatory pathway in a quantitative fashion.

This volume is the first to undertake a large-scale, longue durée study of pain in antiquity across multiple contexts, cultures and genres, providing a close analysis of the articulation of pain experiences, both mental and physical.

This paper develops a metaphysically flexible theory of quantification broad enough to incorporate many distinct theories of objects. Quite different, mutually incompatible conceptions of the nature of objects and of reference find representation within it. Some conceptions yield classical first-order logic; some yield weaker logics. Yet others yield notions of validity that are proper extensions of classical logic.

Fried and Kollár constructed a fully faithful functor from the category of graphs to the category of fields. We give a new construction of such a functor and use it to resolve a longstanding open problem in computable model theory, by showing that for every nontrivial countable structure${\cal S}$, there exists a countable field${\cal F}$of arbitrary characteristic with the same essential computable-model-theoretic properties as${\cal S}$. Along the way, we develop a new “computable category theory”, and prove that our functor and (...) its partially defined inverse are computable functors. (shrink)

Many libertarians believe that self-ownership is a separate matter from ownership of extra-personal property. “No-proviso” libertarians hold that property ownership should be free of any “fair share” constraints, on the grounds that the inability of the very poor to control property leaves their self-ownership intact. By contrast, left-libertarians hold that while no one need compensate others for owning himself, still property owners must compensate others for owning extra-personal property. What would a “self” have to be for these claims to be (...) true? I argue that both of these camps must conceive of the boundaries of the self as including one's body but no part of the extra-personal world. However, other libertarians draw those boundaries differently, so that self-ownership cannot be separated from the right to control extra-personal property after all. In that case, property ownership must be subject to a fair share constraint, but that constraint does not require appropriators to pay compensation. This view, which I call “right libertarianism,” differs importantly from the other types primarily in its conception of the self, which I argue is independently more plausible. (shrink)

Daniel Russell develops a fresh and original view of pleasure and its pivotal role in Plato's treatment of value, happiness, and human psychology. This is the first full-length discussion of the topic for fifty years, and Russell shows its relevance to contemporary debates in moral philosophy and philosophical psychology. Plato on Pleasure and the Good Life will make fascinating reading for ancient specialists and for a wide range of philosophers.

Control of DNA supercoiling by the free-energy of hydrolysis of ATP that involves gene expression is analyzed in terms of three levels of unconnected metabolic pathways. These are synthesis and breakdown of topoisomerase mRNAs, synthesis and breakdown of topoisomerase proteins and supercoiling and relaxation of DNA. The so-called square-matrix method previously developed for the control of metabolic pathways, is extended to deal with this hierarchical control system. It turns out that also in this case, the matrix of control coefficients is (...) equal to the inverse of the so-called elasticity matrix, which contains all relevant elasticity coefficients as well as information about the structure and connectedness of the pathways involved. For a simpler case of a hierarchy of two systems, we demonstrate that the explicit matrix inversion method may be replaced by an implicit method in which the regulatory effects that run through the other level are described by an additional elasticy coefficient which may then be treated as if local. (shrink)

This book develops an Aristotelian account of the virtue of practical intelligence or "phronesis"--an excellence of deliberating and making choices--which ...

1. Happiness, then and now -- Happiness, eudaimonia, and practical reasoning -- Happiness as eudaimonia -- Happiness and virtuous activity -- New directions from old debates -- 2. Happiness then: the sufficiency debate -- Aristotle's case against the sufficiency thesis -- 3. Happiness now: rethinking the self -- Socrates' case for the sufficiency thesis -- Epictetus and the stoic self -- The Stoics' case for the sufficiency thesis -- The embodied conception of the self -- The embodied conception and psychological (...) well-being -- The Stoics' case against the embodied conception. (shrink)

Although scholarship in the social construction of technology has contributed much to illuminating technological development, most work using this theoretical approach is committed to an agency-centered approach. SCOT scholars have made only limited contributions to illustrating the influence of social structures. In this article, the authors argue for the importance of structural concepts to understanding technological development. They summarize the SCOT conceptual framework defined by Trevor Pinch and Wiebe Bijker and survey some of the methodological and explanatory difficulties that arise (...) with their approach. Then the authors present concepts from organizational sociology and political economy that illuminate structural influences in shaping phenomena of interest to SCOT scholars. These structural concepts can be applied to the study of the design, development, and transformation of technology. The authors conclude that the limited amount of scholarship on structural factors in the social shaping of technological development presents numerous opportunities for research. (shrink)

George Herbert Mead is widely considered one of the most influential American philosophers of the twentieth century, and his work remains vibrant and relevant to many areas of scholarly inquiry today. The Timeliness of George Herbert Mead brings together a range of scholars who provide detailed analyses of Mead’s importance to innovative fields of scholarship, including cognitive science, environmental studies, democratic epistemology, and social ethics, non-teleological historiography, and the history of the natural and social sciences. Edited by well-respected Mead scholars (...) Hans Joas and Daniel R. Huebner, the volume as a whole makes a coherent statement that places Mead in dialogue with current research, pushing these domains of scholarship forward while also revitalizing the growing literature on an author who has an ongoing and major influence on sociology, psychology, and philosophy. (shrink)

Virtue ethicists sometimes say that a right action is what a virtuous person would do, characteristically, in the circumstances. But some have objected recently that right action cannot be defined as what a virtuous person would do in the circumstances because there are circumstances in which a right action is possible but in which no virtuous person would be found. This objection moves from the premise that a given person ought to do an action that no virtuous person would do, (...) to the conclusion that the action is a right action. I demon‐strate that virtue ethicists distinguish “ought” from “right” and reject the assumption that “ought” implies “right.” I then show how their rejection of that assumption blocks this “right but not virtuous” objection. I conclude by showing how the thesis that “ought” does not imply “right” can clarify a further dispute in virtue ethics regarding whether “ought” implies “can.”. (shrink)

When subordinates have suffered an unfairness, managers sometimes try to compensate them by allocating something extra that belongs to the organization. These reactions, which we label asmanagerial Robin Hood behaviors, are undertaken without the consent of senior leadership. In four studies, we present and test a theory of managerial Robin Hoodism. In study 1, we found that managers themselves reported engaging in Robin Hoodism for various reasons, including a moral concern with restoring justice. Study 2 results suggested that managerial Robin (...) Hoodism is more likely to occur when the justice violations involve distributive and interpersonal justice rather than procedural justice violations. In studies 3 and 4, when moral identity (trait or primed) was low, both distributive and interpersonal justice violations showed similar relationships to managerial Robin Hoodism. However, when moral identity was high, interpersonal justice violations showed a strong relationship to managerial Robin Hoodism regardless of the level of distributive justice. (shrink)

In this volume of newly commissioned essays, leading moral philosophers offer a comprehensive overview of virtue ethics.

In Philebus, Plato makes clear his view that pleasure is actually part of the agent's own goodness, because her goodness consists in, among other things, the sorts of attitudes she has and perspectives she adopts in the various dimensions of her life, and her pleasure is itself just such a crucial attitude and perspective. When Plato says that pleasure is necessary for happiness, he does not mean that good character could never be enough for happiness without pleasure. Rather, as the (...) dialogue unfolds he reveals that pleasure is actually a part of good character as a whole, the product of reason's transforming all dimensions of the self. Since good character, or virtue, is this sort of whole, pleasure is necessary for happiness, because virtue is sufficient for happiness. Thus, the key to understanding Plato's position can be found in his analysis of the nature of pleasure and how it functions in a person's life. This chapter argues that in Plato's Philebus the pleasure of a virtuous character is necessary and important for happiness because it is a necessary and important part of that character, which, in turn, is what determines happiness. (shrink)

How can an ideal of human flourishing reveal what attributes are virtues, as eudaimonism aspires to do, when not all virtuous lives flourish? The standard answer is that even if circumstances prevent one from attaining that idealized life, still one’s life approximates to the ideal the more one’s character approximates to the ideal. However, exploration of methods of idealization reveals that “approximation” is ill-suited to contexts in which factors interact, as virtue and circumstance do. Instead, eudaimonism helps us understand the (...) distinctive excellence of humans by providing a perspective on what is distinctly human about a distinctly human mode of life, namely practical intelligence in making use of one’s circumstances, whatever they may be. This is an alternative understanding of the method of idealization in eudaimonism about virtue, and so the chapter ends with reflections on some uses and limits of idealization in virtue theory. (shrink)

Idealizations help us understand the world by simplifying it. When factors make discrete contributions to an outcome, leaving factors out can make it easier to identify the contributions of factors that remain. But typically in economics, factors are not discrete but interact; how can isolating some factor X from some factor Y help us understand a reality in which X’s contribution depends on what Y contributes? I argue that Ronald Coase’s method in ‘The Problem of Social Cost’ illustrates how idealization (...) can aid our understanding of a world in which factor Y (transaction costs) has an effect on factor X (transactions), by making plain precisely that effect, and so making it easier to see features of the actual world that obtain because of that effect. ‘Coasean’ idealization is therefore especially useful for understanding targets in which factors are not discrete but interact, as is so often the case in economics. (shrink)

In Republic IX, Plato argues that the supreme pleasantness of the virtuous life is a particularly great consideration in demonstrating that the virtuous life is happy. This raises the question of whether this argument spouses the additive or the directive conception of happiness. On the additive conception, the argument is straightforward: the virtuous life is happy because the virtuous life is also the life of supreme pleasure, and the life of supreme pleasure is happy. On the directive conception, the argument (...) is much more subtle: the virtuous life is happy because the virtuous life is the life of a fully integrated, healthy, and flourishing psyche, as demonstrated by the transformation of the affective dimensions of the virtuous person's psyche, and such a life is the happy life. This chapter set out this need for interpretive care in more detail by looking at its connection to a more general problem for understanding how Plato thinks virtue benefits its possessor in the Republic, to which any adequate reconstruction of the ‘pleasure arguments’ in book IX must respond. It is argued that Plato's strategy is to demonstrate that virtue benefits its possessor on the grounds that the virtuous person, and only the virtuous person, possesses a healthy and harmonious psyche. Plato's conception of pleasure in book IX is a form of apprehending one's life as satisfying and worth living, and his argument is that having the true form of such pleasure means that one's life is, in fact, satisfying and worth living, and that one's psyche is healthy and harmonious. And such pleasure is to be found only in the virtuous person. (shrink)

_Background:_ Weight-related stigma is reported frequently by higher body-weight patients in healthcare settings. Bariatric surgery triggers profound weight loss. This weight loss may therefore alleviate patients' experiences of weight-related stigma within healthcare settings. In non-clinical settings, weight-related stigma is associated with weight-inducing eating patterns. Dietary adherence is a major challenge after bariatric surgery. _Objectives:_ (1) Evaluate the relationship between weight-related stigma and post-surgical dietary adherence; (2) understand if weight loss reduces weight-related stigma, thereby improving post-surgical dietary adherence; and (3) explore (...) provider and patient perspectives on adherence and stigma in healthcare settings. _Design:_ This mixed methods study contrasts survey responses from 300 postoperative bariatric patients with ethnographic data based on interviews with 35 patients and extensive multi-year participant-observation within a clinic setting. The survey measured experiences of weight-related stigma, including from healthcare professionals, on the Interpersonal Sources of Weight Stigma scale and internalized stigma based on the Weight Bias Internalization Scale. Dietary adherence measures included patient self-reports, non-disordered eating patterns reported on the Disordered Eating after Bariatric Surgery scale, and food frequencies. Regression was used to assess the relationships among post-surgical stigma, dietary adherence, and weight loss. Qualitative analyses consisted of thematic analysis. _Results:_ The quantitative data show that internalized stigma and general experiences of weight-related stigma predict worse dietary adherence, even after weight is lost. The qualitative data show patients did not generally recognize this connection, and health professionals explained it as poor patient compliance. _Conclusion:_ Reducing perceptions of weight-related stigma in healthcare settings and weight bias internalization could enhance dietary adherence, regardless of time since patient's weight-loss surgery. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Virtue as "Likeness to God" in Plato and SenecaDaniel C. Russell (bio)In The Center Of Raphael's Famous Painting"The School of Athens," Plato stands pointing to the heavens, and Aristotle stands pointing to the ground; there stand, that is, the mystical Plato and the down-to-earth Aristotle. Although it oversimplifies, this depiction makes sense for the same reason that Aristotle continues to enjoy a presence in modern moral philosophy that (...) Plato does not: quite simply, Plato's ethics looks too fantastic. And Plato's ethics never looks more fantastic than in the claim that our highest good is to be like God.We find this view, in various forms, in the Phaedrus, Timaeus, Laws, Republic, and Theaetetus, as well as in the Phaedo and Philebus,1 and the ancient Platonist Alcinous in his Handbook of Platonism tells us that likeness to God () is Plato's "official" position on our final end.2 Nonetheless, this view receives very little press today: many philosophers are unaware of it; some have simply ignored it or dismissed it as an idle metaphor; and most of those who have taken it more seriously have also tended to find it too otherworldly to be of much relevance to us. This latter response is due in large measure to viewing likeness to God from the perspective of the ancient Neoplatonist Plotinus.3 But there is certainly no guarantee that Plotinus's perspective on likeness to God gives us an especially accurate reconstruction of Plato's view; indeed, the interpretation of this idea was a matter of considerable controversy among Neoplatonists, some of whom offered far less other-worldly interpretations than Plotinus's.4 [End Page 241]In any event, unraveling likeness to God in Plato requires a fresh approach that makes the greatest sense of it within Plato's larger moral philosophy. And in fact we find just such a promising understanding of likeness to God when we take a fresh look at it through Stoic lenses, and through the lens of Plato's Philebus: in both we find the idea that virtue is part of the divine realm right alongside the down-to-earth idea that virtue is rational activity in relation to the world as we find it. This is not to suppose that the Stoic conception of likeness to God is an interpretation of, or descended from, Plato's conception.5 It is simply that the Stoics also found it helpful to think of virtue as likeness to God, and it will be enough if the Stoic conception opens up the range of possibilities for understanding such an idea, allowing us to see philosophical alternatives that might take us some distance towards interpreting Plato, and that may have remained otherwise out of view. Such an understanding of the idea that virtue is likeness to God as we find in the Stoics, I argue, offers just this sort of promising and unexplored alternative in Platonism.One thing that is quite clear is that Plato means for likeness to God to offer us some insight into the nature of virtue. We see this in the Timaeus, where Plato offers a model of the three-part soul, in which mastery of the parts is justice (42 a-b) and happiness (90b-d), and is what likeness to God comes to (42b-d, 47a-c); clearly, then, the virtue in question is moral virtue. Rather curiously, Plato depicts this constitution of soul as a sort of motion which is of the same kind as the motion of the universe itself (90c-d):6 as the universe consists in orbits which are orderly and reconciled in their motion, so the human soul consists in the different orbits (44d) of reason, passion, and desire, which are out of harmony when we start life, but become more orderly as we mature (43a-44d). Although this is difficult talk, it is clearly meant to depict a self-mastery of the whole soul under [End Page 242] the leadership of reason (43a-44d), which is the same as justice, and which consists in the reconciliation of one's inner motions by reason (42b-d).7 Thus we "stabilize the... (shrink)

The aim of this volume is to examine this claim, and to place it in the wider context of recent epistemological debates about the role of sociality in knowledge acquisition.

This book is open access, which means that you have free and unlimited access. This book analyses and discusses the recent developments for assessing research quality in the humanities and related fields in the social sciences. Research assessments in the humanities are highly controversial and the evaluation of humanities research is delicate. While citation-based research performance indicators are widely used in the natural and life sciences, quantitative measures for research performance meet strong opposition in the humanities. This volume combines the (...) presentation of state-of-the-art projects on research assessments in the humanities by humanities scholars themselves with a description of the evaluation of humanities research in practice presented by research funders. Bibliometric issues concerning humanities research complete the exhaustive analysis of humanities research assessment. The selection of authors is well-balanced between humanities scholars, research funders, and researchers on higher education. Hence, the edited volume succeeds in painting a comprehensive picture of research evaluation in the humanities. This book is valuable to university and science policy makers, university administrators, research evaluators, bibliometricians as well as humanities scholars who seek expert knowledge in research evaluation in the humanities. (shrink)

The human and mouse genomes are complex from a genomic standpoint. Each cell has the same genomic sequence, yet a wide array of cell types exists due to the presence of a plethora of regulatory elements in the non‐coding genome. Recent advances in epigenomic profiling have uncovered non‐coding gene proximal promoters and distal enhancers of transcription genome‐wide. Extension of promoter‐associated H3K4me3 histone mark across the gene body, known as a broad H3K4me3 domain (H3K4me3‐BD), is a signature of constitutive expression of (...) cell‐type‐specific regulation and of tumour suppressor genes in healthy cells. Recently, it has been discovered that the presence of H3K4me3‐BDs over oncogenes is a cancer‐specific feature associated with their dysregulated gene expression and tumourigenesis. Moreover, it has been shown that the hijacking of clusters of enhancers, known as super‐enhancers (SE), by proto‐oncogenes results in the presence of H3K4me3‐BDs over the gene body. Therefore, H3K4me3‐BDs and SE crosstalk in healthy and cancer cells therefore represents an important mechanism to identify future treatments for patients with SE driven cancers. (shrink)

Abstract:In this essay I examine restrictions on labor as takings of property: a liberty to work is property, and restrictions of that liberty are takings. I set property in one’s labor within a unified framework for all forms of property, understood as a social institution for balancing two freedoms: freedom to act even if it interferes with someone else, and freedom from interference. As such, property includes not only possession but also use and disposition. To restrict use or disposition is (...) to alter those freedoms, which is a taking of property, including property in one’s labor. I understand such takings to be justified insofar as they benefit the persons whose freedoms are altered, taking up the question of when restrictions on use and disposition of labor are to the benefit or the harm of excluded workers. Appreciating that labor is property, and that restrictions on labor are takings, reframes the justificatory burden that restrictions on labor must bear. And where that justification is lacking, this approach reframes the nature of the wrongs that unjustified restrictions perpetrate, especially against the most vulnerable workers. (shrink)